The common feature is a preponderance of 1 6linked. Jul 03, 2018 iron dextran is injected into a vein through an iv. The molecular weight of the fraction is in most cases a key property and is defined in terms of the average molecular weight mw 2 and the number average molecular weight mn 3. Repeat dosage of dextran 1 if more than 15 minutes elapses during infusion. Iron dextran injection is in a class of medications called iron replacement products. Iron dextran is approved for the treatment of iron deficiency when oral iron preparations are ineffective or cannot be used. Dextran 1 should be given just before infusing low or highmolecularweight dextran. Dextran chains are of varying lengths from 3 to 2000 kilodaltons the polymer main chain consists of. Dextran net charge and fixability we employ succinimidyl coupling of our dyes to the dextran molecule, which, in most cases, results in a neutral or anionic dextran. Administer 20 ml dextran 1 before administration of dextran 40. Intravenous iron supplies enough iron to permit rbc formation greater than 50. Compatibility of xanthan gum solutions 12 acids 12 bases 12 salts 12 thickeners.
Infed iron dextran side effects, images, uses, dosage. Always have resuscitation equipment and personnel trained in the detection and treatment of anaphylactictype reactions readily available during dexferrum adminisration. Plasma is needed to circulate red blood cells that deliver oxygen throughout the body. Iron dextran injection is commercially available as a sterile solution of iron dextran complex containing 5% iron and 20% dextran. Infed, iron dextran ivim, 50mgml, sdv, 2mlvial mcguff. In the present investigation, the data obtained are for leuconostoc mesenteroides nrrl b512 and its watersoluble dextran. Dextran, high molecular weight side effects, dosage. Ferric hydroxide 100 or ferric oxyhydroxide 101 in a complex with partially hydrolyzed low molecular weight dextran. Infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Do not selfinject this medicine if you do not understand how to give the injection and properly dispose of used needles, iv tubing, and other items used to inject the medicine. However, other methods indicate branches of greater than 50 glucose units exist.
Dextran polymeric chains showed fast hydration kinetics with high amount of water absorbed, which turned into fast dissolution or fast swelling as a function of the molecular weight. May be given direct iv or further diluted in 50ml nsd5w. Test dose, observation recommended for iron dextran. Uses for iron dextran iron deficiency not amenable to oral iron therapy. Infed, dexferrum iron dextran complex dosing, indications. For prevention they are only recommended in those with poor absorption, heavy menstrual periods, pregnancy, hemodialysis, or a diet low in iron. Iron dextran injection is used to treat irondeficiency anemia a lower than normal number of red blood cells due to too little iron in people who cannot be treated with iron supplements taken by mouth. Dextran handbook introduction to dextran a comprehensive presentation of the chemical and physical properties, structure, stability, biocompatibility, and biodegradability of dextran fractions is given in the dextran handbook. The reaction used to produce the rhodamine green and alexa fluor 488 dextrans results in the final product being neutral, anionic, or cationic. Dextrans are a family of highmolecularweight polymers composed of dglucose units interconnected with. If test dose uneventful, give the remainder of the total dose as 100 mg elemental iron per day im or iv until the total calculated dose is given.
Prior to the first therapeutic dose, administer a test dexferrum dose of 0. Each ml contains the equivalent of 50 mg of elemental iron as an iron dextran complex, approximately 0. The remainder of the dose may be given over the last hour of dialysis. Precipitation of calcium phosphate when calcium and phosphate salts are added can be affected by ph, amino acid concentration, amino acid. Any of several watersoluble high molecular weight glucose polymers ranging between mw 1,000 and 40,000,000. She said that the test dose is given ad then they give the benadryl right before the treatment begins. She said it is about 20 minutes between the test dose. Cosmofer summary of product characteristics smpc emc. A list of compatible smart devices for the dexcom mobile apps available in the united states and internationally. Infed iron dextran dose, indications, adverse effects.
The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. It is composed of approximately 95% alphad16 linkages. Iron dextran is used to treat iron deficiencies and iron deficiency anemia low red blood cells. Iv geriatric patients, debilitated patients, or asa iii iv patients. Iv ozone, high dose vitamin c booklet index page no. Iron dextran side effects, dosage, interactions drugs. Incompatibilities are based on meeting any of the following criteria. Intravenous iron supplies enough iron to permit rbc formation greater. Bemiller, in encyclopedia of food sciences and nutrition second edition, 2003. We have been successfully audited by several large pharmaceutical companies from canada, usa and europe. Initially, 500 ml of a 10% solution in sodium chloride 0.
Severe blood loss can decrease oxygen levels and can lead to organ failure, brain damage, coma, and possibly death. The structure of an individual dextran varies with the strain of microorganism. It works by replenishing iron stores so that the body. Nov 09, 2018 iron dextran is a form of the mineral iron. This medication is usually injected deep into the muscle of the buttock or slowly into a vein as directed by your doctor.
Infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use each ml contains the equivalent of 50 mg of elemental iron as an iron dextran complex, approximately 0. May 02, 1980 intravenous iron dextran in clinical medicine. Dextran is a generic term for a family of glucans made by polymerization of the. This characteristic branching distinguishes a dextran from a dextrin, which is a straight chain glucose polymer tethered by.
Hi everyone, i am going in tomorrow for my first iron dextran infusion and i am a bit concerned after speaking to the nurse about it and reading the side effects. Dextran is a complex branched glucan polysaccharide derived from the condensation of glucose. Treatment of iron deficiency when oral iron preparations are ineffective or cannot be used. Protocol for the use of intravenous iron dextran cosmofer. Molecular weight and size dextran fractions are supplied in molecular weights from 1,000 daltons to 2,000,000 daltons 1. Iron is important for many functions in the body, especially for the transport of oxygen in the blood. For solution and drug compatibility information, see compatibility under stability. The form infed elemental iron, 50 mgml, low molecular iron is given both iv and im, while the form dexferrum elemental iron, 50 mgml, high molecular iron dextran is given only iv and is administered slowly. Iron dextran is injected into a vein through an iv. Iron dextran injection contains 50 mg of elemental iron per ml.
Iron dextran vc iron sucrosea c ixabepilone ii c leucovorin cv c c1,3 i1 c1,2,3 c1 1,3 c1 c1 1 1 1,3 1 i1 c1 c1 c2 1 1,3i2 c1,3 c 1c 1c c c 1c c 1,3c 1,3c 1c 1c 1c i c c c1 c1 c1 c1 c c c levoleucovorin cc v2 c1 lorazepam vv v i 1c 1c c c1,3 c 1c c c 1c i 1c c cabazitaxel c iv compatibility guide. Compatibility considerations in parenteral nutrient solutions. Nevertheless, these results suggest other uses for dextrans in tablet formulation both in pharmaceutical and nutraceutical products. Iron dextran is used to treat iron deficiencies and iron deficiency anemia low red blood cells iron dextran may also be used. Dextran 40 definition of dextran 40 by medical dictionary. Dec 12, 2019 lmd dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran average mol. Nov 09, 2018 highmolecular weight dextran is a plasma volume expander made from natural sources of sugar glucose. Dexferrum iron dextran injection, usp rx only warning. Cosmofer in a dose of 100200 mg iron 24ml may be diluted in 100 ml. Four hundred seventyone adult patients and ten adult prisoner volunteers received 2,099 intravenous iv injections of iron dextran imferon, usually 250 to 500 mg at less than 100 mgmin. Iron supplements, also known as iron salts and iron pills, are a number of iron formulations used to treat and prevent iron deficiency including iron deficiency anemia.
Many antibiotics are probably stable, especially when administered by coinfusion rather than by. Protocol for the use of iv iron dextran cosmofer iv iron dextran cosmofer protocol page 10 of 11 author. Additive compatibility drugs in syringe compatibility. Miers from the starch and dextrose division, northern regional research laboratory, peoria, illinoist received for publication, june 21, 1948. Conflicting data on the branch lengths implies that the average branch length is less than three glucose units. The maximum iv im dose of undiluted iron dextran is 100 mg 2 ml per day. Dextran, amino, 70,000 mw thermo fisher scientific.
In most cases the length of the side chains is short, and. Trissel, fashp, 2010, american society of healthsystem pharmacists. At a mean followup of 6 weeks after the administration of iv iron dextran, hemoglobin levels had significantly increased by a mean of 1. May 26, 2015 infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron deficiency easily treated with iv dextran medscape. Dextran and its potential use as tablet excipient sciencedirect. Gentran, lmd dextran dosing, indications, interactions. Protocol for the use of iv iron dextran cosmofer iv iron dextran cosmofer protocol page 7 of 11 author. Iron dextran is a stable, clear brown solution available in 2 and 5ml ampuls and a 10ml multipledose vial.
This product requires a verified medical license to purchase. Physical properties of dextran molecular weight and size dextran fractions are supplied in molecular weights from 1,000 daltons to 2,000,000 daltons 1. The first edition of this booklet was published in 1972. Also described as low viscous or low viscosity dextran, dextran 40 is prepared by acid hydrolysis and differential fractionation. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. Find out what health conditions may be a health risk when taken with dextran 40 10 % in 0. Webmd provides common contraindications for dextran 40 10 % in 0. It works by restoring blood plasma lost through severe bleeding. The formation of dextran in wine was shown by pasteur to be due to the activity of microbes. Jul 03, 2018 infed iron dextran injection usp is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Dextran infusion concerned first timer healthboards. Dextran chains are of varying lengths from 3 to 2000 kilodaltons. Dextran definition is any of numerous glucose biopolymers of variable molecular weight that are produced especially by the fermentation of sucrose by bacteria such as genus leuconostoc, are found in dental plaque, and are used especially in blood plasma substitutes.
More information is available on the fda web site any serious adverse. Indications and dosages prevention of severe anaphylactoid reaction caused by low or highmolecularweight dextran. On each occasion the first 25 mg of iron should be infused over a period of 15 minutes. Highmolecular weight dextran is a plasma volume expander made from natural sources of sugar glucose. With a wide array of applications for our dextran based product line, we have established a loyal customer base in europe, united states, canada, the pacific rim and other locations across. Lmd dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran average mol. The remaining a linkages account for the branching of dextran. Dextrans, a group of polysaccharides composed of glucose, are secreted by certain strains of bacteria as slimes. Avoid doses that exceed recommendations because doserelated increases in wound hematoma, wound seroma, wound bleeding, occult bleeding such as hematuria and melena, and.
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